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And 30-min groups are not significantly different from one another. The 6-hr interval group is not significantly dif ferent from the concomitant administration group. These data seem to indicate that there is significant synergism in this drug pair if intervals between the 2 agents are less than 6 hr. The synergism is in the opposite direction from the MTX-5-FU study, in that IM must precede MTX in order to see potentiation. The effect of the opposite direc tion MTX then IM ; is seen in Chart 5. Effect of MTX Followed at Various Times by IM on HPFC Production. As shown in the previous figure, the concomitant administration of IM and MTX results in 66.6% inhibition of HPFC production. When MTX preceded the administration of IM by min, 30 min, l hr, or 6 hr, there was no marked difference from the con comitant administration group. The 15-min interval group, however, did result in a slightly greater percentage in hibition 76% ; which was significantly different from the concomitant group. Thus in this direction there was no antagonism nor was there marked synergism.

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Non-current liabilities: The increase in non-current liabilities from 1 601 million euro to 4 199 million euro is mainly a consequence of the new financing contracted for the Schwarz Pharma acquisition, the recognition of the non-current liabilities of Schwarz Pharma entering UCB's consolidation scope, including the deferred tax liabilities impact on intangible assets reflecting the acquired assets. Current liabilities: The increase of the current liabilities from 747 million euro to 1 023 million euro, not considering Schwarz Pharma, is the result of the increase in trade payables and other short-term liabilities as well as income taxes payable on higher pre-tax income. Including Schwarz Pharma's current liabilities, the amount increases by 498 million euro to reach 1 521 million euro, reflecting 90 million euro of trade payables, 93 million euro of current income tax liability as well as short-term provisions and short-term liabilities. Net debt: The net debt of 2 111 ; million euro reflects the combined position of UCB and Schwarz Pharma as of 31 December 2006, including the impact of the purchase of the portion paid in cash of the 86.8% shares in Schwarz Pharma. UCB's net debt position on a standalone basis, without the incremental debt assumed for the acquisition, would have decreased from 591 ; million euro at the end of 2005 to 339 ; million euro at the end of 2006. The cash position of Schwarz Pharma as of 31 December 2006 was 263 million euro, whilst the incremental debt resulting from the payment of the cash portion of the Schwarz Pharma shares acquired amounted to 2 043 million euro, for example, lotrim8n thrush.
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