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It was not in my paradigm that something like this could ever happen, " explains Lisa. She had no family history of kidney disease and was very athletic, riding her bike to work each day and hiking with husband Kurt on the weekends. Immediately after her diagnosis, Lisa started hemodialysis while continuing to work full-time in a public relations career. Within weeks of starting dialysis, Lisa met with California Pacific Medical Center's Kidney Transplant Team and was listed for a transplant. Her family and husband were tested to see if they could donate and surprisingly, her husband Kurt was the best match. While Lisa and Kurt were hopeful about the transplant, she learned that her antibody levels were too high to obtain a kidney transplant. With high antibodies, one's body recognizes a new kidney as a foreign object and attacks the organ. "It took about six months for my antibody levels to drop, then we had to wait another six months to ensure they remained in the normal limits for transplantation, " says Lisa. In March 2000, her transplant occurred and Kurt.
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Because serotonergic cell bodies or processes are present in the entire CNS, and 5-HT is known to exert diverse modulatory actions, it was of interest to determine whether 5-HT release evoked by tail nerve stimulation is widespread or restricted to specific regions of the CNS. To examine this question, we first measured 5-HT signals in two different locations within the pedal ganglion. The CFEs were first implanted as before, underneath the tail MNs Fig. 8, top, region A ; , and then moved to a second recording site, 500 m more caudal Fig. 8, top, region B ; . Serotonin signals evoked by tail nerve stimulation were recorded in both sites. Tail nerve stimulation for 2 sec at 40 Hz evoked clear 5-HT release in the vicinity of the tail MNs 35 14 pA; n 8 ; but not 500 m more caudally Fig. 8, bottom ; . Indeed, 5-HT signals were completely undetectable at this second location in all but one of the eight preparations examined. This effect was not attributable to a loss of sensitivity of the CFEs after deeper penetration into the ganglia, because when the electrode was pulled back to the first recording area, clear 5-HT release was again still detected n 2 ; . second set of experiments, we determined the degree of lateralization of 5-HT release within the CNS. The ring ganglia were kept intact Fig. 9A ; , with the right pleural and pedal ganglia desheathed as before see Materials and Methods ; . The left and right tail nerves were then connected to suction electrodes to allow electrical stimulation of the ipsilateral or contralateral side. Serotonin signals in the pleural and pedal ganglia were comparable, with maximal signals always evoked by ipsilateral stimulation 44 17 pA the pleural ganglion and 44 15 pA the pedal ganglion; n 6 ; and minimal signals by contralateral shock 5 pA the pleural ganglion and 4 pA the pedal ganglion; n 6; p 0.01; Fig. 9B, C ; . The signals evoked by contralateral shocks were often close to the detection limit of the CFE but could be identified unequivocally in 5 of cases Fig. 9B, Pedal ; . Thus, there is clear functional lateralization of 5-HT release in response to tail nerve stimulation.
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